Not with the standard select box binder but if you change to use JDBC Options Binder to read from the database, you can use CONCAT() to string together a few fields to display as one, for example:
SELECT id, CONCAT(c_field1,c_field2,c_field3) AS desc FROM app_fd_lookuptable
Now the popup select box displays only "title" column , is there any way to display more than one columns